After the construction of cascade reservoirs in the Three Gorges and its upper reaches, the downstream clear water of the dam was discharged, and a long-term and long-distance erosion occurred in the middle and lower reaches of the Yangtze River. From Yichang to the Yangtze Estuary, a total of 5030 million m³ was scoured. Under the background of large-scale erosion in the middle and lower reaches of the Yangtze River, it has a profound impact on river regime, flood control and shipping. The analysis shows that the river regime in the middle and lower reaches of the Yangtze River is generally stable, and the river regime in some parts of the river changes greatly, resulting in the phenomenon of beach cutting and bending, and the phenomenon of strong trunk. The increase of channel storage capacity increases the capacity of river discharge and flood storage, but the change of flow top scour point and the erosion of nearshore riverbed also make the river bank collapse frequently, affecting the stability of river regime and flood control safety. Under the combined action of channel scour, river regime control and channel engineering, channel conditions in the middle and lower reaches of the Yangtze River improved overall. However, due to the unbalanced scouring of the river channel, the sandy pebble river section in the downstream of the dam has a 'steep slope and rapid flow’, and the sandy river section has phenomena such as scattered beaches and channel displacement, affecting the channel conditions; the continuous erosion of river bed results in the decrease of low water level, which affects the water supply safety of life, production and ecology along the middle and lower reaches of the Yangtze River in extremely dry years. The relationship between rivers and lakes has undergone new changes. The three diversion channels have changed from original siltation to erosion. The water levels in the two lakes have decreased to varying degrees, and the low water level has appeared earlier, which has adversely affected the water resources and ecological environment in the lake area. The regulation of water replenishment and saltwater intrusion in dry season of the Three Gorges Project and the slowing down of siltation in the north branch are beneficial to the control of saltwater intrusion in the Yangtze Estuary. The sediment discharged into the sea from the Yangtze Estuary is significantly reduced and the riverbed near the Yangtze Estuary is scoured strongly. It seriously threatens the safety of the main structure of coastal enterprise wharf.